Largest RNA language model to date offers new way to predict behavior and boost drug discovery

RNA plays a vital role in how our genes are expressed and how diseases develop. Yet, because RNA molecules constantly change ...
Nature

HIV-1 A-rich RNA loop mimics the tRNA anticodon structure

Figure 1: a, Sequence and secondary structure of the A-rich loop of HIV-1 RNA. These possible mechanisms should be investigated further by biochemical and genetic experiments. The RNA molecules of HIV ...
KTBS 3

New Approach Could Make Gene-Editing Treatments Faster and Cheaper

Rodolphe Barrangou, a genomic-editing expert at North Carolina State University who was not involved in the research, said ...

Understanding intrinsically disordered protein regions and their roles in cancer

Every function in a cell is associated with a particular protein or group of proteins, typically in a well-defined ...

Gene therapy for sickle cell and β-thalassemia works by disrupting three-dimensional genome structure

Scientists at St. Jude Children's Research Hospital and Northwestern University identified a previously unknown treatment ...
eLife

Investigation of All Disease-Relevant Lysine Acetylation Sites in α-Synuclein Enabled by Non-canonical Amino Acid Mutagenesis

This valuable work provides new insights into the role of lysine acetylation of alpha-synuclein, the protein involved in Parkinson's Disease. The evidence is mostly solid, but the claims around the ...
eLife

Multi-barrier unfolding of the double-knotted protein, TrmD–Tm1570, revealed by single-molecule force spectroscopy and molecular dynamics

This study investigates the folding and unfolding behavior of the doubly knotted protein TrmD-Tm1570, providing insight into the molecular mechanisms underlying protein knotting. The findings reveal ...
Hosted on MSN

‘He functions as a king because he can’t lead as a president’: Analyst on Trump after SNAP ruling

Many Americans might have to decide between paying for food or rent if their SNAP food-aid benefits are suddenly cut off. Mychael Schnell and Michele Norris join The Weekend to discuss Trump’s ...
WTOC-TV

Savannah Fire responds to structure fire on Martin Luther King Jr. Blvd. and W 33rd Street.

SAVANNAH, Ga. (WTOC) - Savannah Fire Department is responding to a structure fire on Martin Luther King Jr. Blvd. and W 33rd Street. The fire department says just before 7:30 p.m. Friday, crews were ...
Nature

tRNAs articles from across Nature Portfolio

Transfer RNAs (tRNAs) are a type of non-coding ribonucleic acid (ncRNA) that carry specific amino acids and recognize unique messenger RNA (mRNA) sequences. The pairing of a tRNA to its compatible ...