As replication forks progress along the genome, they face many challenges including DNA damage lesions, strand breaks and DNA binding proteins which may cause the replication fork to pause or stall.
Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment ...
In the nucleus of the infected cell, influenza polymerase (FluPol) uses the viral genomic RNA (vRNA) as template to perform synthesis of either capped and polyadenylated viral mRNA (transcription), or ...
For the first time, scientists at the Morgridge Institute for Research have generated near atomic resolution images of a major viral protein complex responsible for replicating the RNA genome of a ...
A new study published in Nature Structural & Molecular Biology reveals how the fundamental enzyme called DNA polymerase delta operates during DNA replication, making a copy of the genetic code that ...
Plasmids, small circular DNA molecules found in bacteria, may contain antibiotic-resistance genes and have the ability to replicate independently. Bacteria can transfer these plasmids to one another, ...
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