p130 is a member of the retinoblastoma family of pocket proteins, which includes pRB and p107. Unlike pRB and p107, p130 protein levels decrease dramatically following its hyperphosphorylation ...

Senescence is the process of cellular aging dependent on the normal physiological functions of non-immortalized cells. With increasing data being uncovered in this field, the complex molecular web ...

Extravesical tumor relapse in patients with superficial bladder tumors. The retinoblastoma gene is the prototype of tumor-suppressor genes and has been shown to be involved in the pathogenesis and ...

A new study uncovers mechanisms that control Rb2/p130 gene expression in lung cancer and reveals why the gene is expressed differently in small and non-small lung cancer cells. Despite innumerable ...