To balance X-linked gene dosage between males and females, female mammals silence one X chromosome in each cell. In eutherian embryos, X-inactivation is random such that each X has an equal ...
SF2/ASF is a prototypical serine- and arginine-rich protein, with important roles in splicing and other aspects of mRNA metabolism. Splicing factor, arginine/serine-rich 1 (SFRS1), the gene encoding ...