Investigators led by Navdeep Chandel, Ph.D., the David W. Cugell, MD, Professor of Medicine in the Division of Pulmonary and Critical Care, have discovered how the metabolism of mitochondria supports ...

We owe a lot to tissue resident memory T cells (T RM). These specialized immune cells are among the body's first responders to disease. Rather than coursing through the bloodstream-as many T cells ...

Memory T cells are a special type of white blood cell that "remember" past infections and vaccines, helping our bodies to quickly respond if we encounter the same germs again. These cells are found ...

Findings from St. Jude Children's Research Hospital demonstrate that virtual memory T cells, a specialized group of immune cells, provide nonspecific immunity for infants early in life. The work stems ...

Pre-wired ability in ‘resting’ T cells to remember past viral foes discovered, a promising breakthrough for targeted cancer therapies. A team of immunologists at the University of Massachusetts ...

Peptide vaccine-treated, long-term surviving cancer patients harbor self-renewing tumor-specific CD8 + T cells Fig. 1: Transfer of activated and tumor antigen-loaded splenic cDC1s outperforms cDC2s in ...

Scientists analyzing human and mouse pancreatic lymph nodes (PLNs) and spleens have identified a distinct subset of CD4 memory helper T cells associated with type 1 diabetes (T1D). Reported by ...

Fig. 5: TCF1 and BCL6 support the generation of Tsm, while BHLHE40 supports their differentiation into proinflammatory progeny in cGVHD target tissues. Fig. 6: Donor MHCII-mediated indirect ...

When cells are healthy, we don't expect them to suddenly change cell types. A skin cell on your hand won't naturally morph into a brain cell, and vice versa. That's thanks to epigenetic memory, which ...

However, details of the intervening steps, as researchers have learned in the past 65 years, are quite complex — certain cells carry the flu antigen to the immune system, specific immune cells respond ...