It was called ‘complement’ because it aided the antibacterial activity of antibodies. However, it is now known that the complement system can be activated early in an infection without the presence of ...

To survive in the human host, bacteria have developed many different strategies to escape the innate immune response, including the expression of an extracellular capsule and 'hiding' within host ...

COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the largest pandemic disease of humans in the past century. Thus far, approximately 225 million cases and more than ...

Long Covid patients suffer from chronic symptoms such as fatigue or shortness of breath. As researchers have discovered, this is to some extent due to a part of our immune system called the complement ...

Immunotherapy is increasingly becoming standard therapy in cancer, with technology, such as checkpoint inhibitors and cell therapy, raising the efficacy bar in many forms of the disease. But the ...

Anti-HLA antibodies hamper successful transplantation, and activation of the complement cascade is involved in antibody-mediated rejection. We investigated whether the complement-binding capacity of ...

Age-related macular degeneration is the most common cause of blindness in Western populations. Susceptibility is influenced by age and by genetic and environmental factors. Complement activation is ...

Complement 3 glomerulopathy (C3G) is a rare kidney disease that affects your body’s innate immune system (complement system). Complement 3 glomerulopathy (C3G) is a kidney disease that’s caused by ...

Although the vaccine cavalry is finally coming over the hill, the need for better drugs to treat those with COVID-19 remains. Many drugs are being tested in patients at different stages of the disease ...