It may seem counterintuitive, but could BACE2 protect against amyloidosis, rather than contribute to it? This is the central question in a manuscript posted to bioRxiv. Non-amyloidogenic processing of ...
The inhibitors of the β-site APP-cleaving enzyme 1 (BACE1) that are in clinical trials to prevent Alzheimer’s dementia block the activity of BACE2, as well. Alas, the function of this less-studied ...
Brain organoids grown from the reprogrammed hair cells of people with Down syndrome have revealed a gene that can act as a natural suppressor of Alzheimer’s disease. Around 70% of people with Down ...
The Mayo research team, led by Malcolm A. Leissring, Ph.D., a neuroscientist at Mayo Clinic in Florida, made the discovery by testing hundreds of enzymes for the ability to lower beta-amyloid levels.
An enzyme could represent a powerful new tool for combating Alzheimer’s disease. An enzyme that could represent a powerful new tool for combating Alzheimer's disease has been discovered by researchers ...
A Queen Mary University of London-led team of scientists harnessed induced pluripotent stem cell (iPSC) technology and hairs donated by individuals with Down syndrome (DS), to develop a rapid in vitro ...
One of the holy grails in diabetes research is to discover molecules that stimulate beta cell growth and to find drugs that target these molecules. Now researchers have done both, discovering not only ...
JACKSONVILLE, Fla. — An enzyme that could represent a powerful new tool for combating Alzheimer's disease has been discovered by researchers at Mayo Clinic in Florida. The enzyme — known as BACE2 — ...
Some results have been hidden because they may be inaccessible to you
Show inaccessible results