Tucci starred alongside Meryl Streep and Anne Hathaway in the 2006 classic as the fashion-obsessed art director at Runway magazine. Throughout the film, he takes Andy (Hathaway) under his wing and helps her navigate working as the assistant to Runway editor-in-chief Miranda Priestly (Streep.)

Tucci continued to play a staggeringly diverse array of characters, from the sadistic serial killer George Harvey in The Lovely Bones (which earned him an Academy Award nomination in 2009), to Jack Warner, the pugnacious studio boss in the miniseries Feud: Bette and Joan (which earned him an Emmy nomination in 2017).